Defining the optimal animal model for translational research using gene set enrichment analysis
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چکیده
منابع مشابه
Defining the optimal animal model for translational research using gene set enrichment analysis
The mouse is the main model organism used to study the functions of human genes because most biological processes in the mouse are highly conserved in humans. Recent reports that compared identical transcriptomic datasets of human inflammatory diseases with datasets from mouse models using traditional gene-to-gene comparison techniques resulted in contradictory conclusions regarding the relevan...
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BACKGROUND Gene set enrichment analysis (GSEA) is an analytic approach which simultaneously reduces the dimensionality of microarray data and enables ready inference of the biological meaning of observed gene expression patterns. Here we invert the GSEA process to identify class-specific gene signatures. Because our approach uses the Kolmogorov-Smirnov approach both to define class specific sig...
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Gene set enrichment analysis (GSEA) is typically based on tests derived from the KolmogorovSmirnov, which is underpowered and a need for simpler methods has been identified.[2] The wgsea package contains functions for conducting GSEA using a Wilcoxon test to test for differences in the distribution of p values between SNPs within the gene set under test and a control set of SNPs. The mean of th...
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15 صفحه اولAbsolute enrichment: gene set enrichment analysis for homeostatic systems
The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include one limb that is upregulated in response to a downregulation of another limb and vice versa. Such patterns are poorly captured by the standard formulation of GSEA. We describe a technique to identify groups of genes (which sometimes can be pa...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2016
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201506025